I did this with Qubes a year ago and haven’t had any issues apart from figuring out the right flags to get the full performance, otherwise the GPU would cap around 30% under load with low CPU load.
Kind of at the mercy of what your motherboard and bios will allow, mine I had to cheese a little and disable the PCI device on boot so I get to decrypt my disk with no screen lol but it works!
Not op but I do a lot of architecture and infrastructure work on top of my normal dev work so keeping everything separated and per-client has become a pretty important advantage for me personally
Fwiw I had to tinker a bit to get good video playback, Fedora was always choppy for me for some reason but debian is typically smooth with hw accel disabled.
As for the gaming, depending on your setup (I have a desktop and T480 I keep in sync) you can absolutely run two video cards and do PCI passthrough on one to a gaming VM. I have mine set up with a dedicated NIC and USB card and just use a KVM to swap between Qubes and Windows (for now) and it’s worked really well. Had to play around a ton to get the full speed out of the GPU though and it only seemed to work in windows so hopefully get that going for a Linux hvm one day.
Absolutely agree there is no going back, I have all of my work stuff entirely hardware agnostic and a full on replica of my work desktop ready to go in a moment should the desktop die. Apart from that keeping client work isolated has been such a game changer.
I literally bought the wrong version of a game called Heretic on Amazon in the early 2000s because it “had a cool penguin on it” lmao
My brother needed the driver installed in debian on Qubes but has been flawless beyond that. When I was still running arch it just worked out of the box